منابع مشابه
Lipid activation of protein kinases.
Lipids acutely control the amplitude, duration, and subcellular location of signaling by lipid second messenger-responsive kinases. Typically, this activation is controlled by membrane-targeting modules that allosterically control the function of kinase domains within the same polypeptide. Protein kinase C (PKC) has served as the archetypal lipid-regulated kinase, providing a prototype for lipi...
متن کاملP20: The Role of Protein Kinases in Memory
When an experience is encrypted into a long-lasting memory, it is believed that specific sets of neurons in the brain of the animal undergo changes including the strengthening of preexisting synapses and the growth and maintenance of new synaptic connections. These activity-dependent synaptic changes appear to require the coordination of a variety of cellular processes in spatially separated ce...
متن کاملProtein kinases: Getting NEKed for S6K activation
The 70/85 kDa ribosomal protein S6 kinase is regulated through the concerted actions of multiple phosphatases and kinases. A newly identified S6 kinase kinase, NEK6, appears to provide the penultimate activation step.
متن کاملLipid modifications of G-protein-coupled receptor kinases.
Introduction G-protein-coupled receptors recognize a wide variety of extracellular ligands and stimuli. These include hormones, neurotransmitters, neuromodulators, Ca2+ ions, tastants, odorants and photons [l-31. This family of receptors may number over 1000 members and is characterized by a seven-transmembrane-spanning architecture. Signal transmission is initiated by a receptor conformational...
متن کاملLipid-mediated protein delivery of suicide nucleoside kinases.
Nucleoside kinases from several species are investigated as suicide genes for treatment of malignant tumors by combined gene/chemotherapy. In the present study, we have investigated a novel strategy where nucleoside kinase proteins are directly delivered to cells without delivery of genetic material. We used a mix of a trifluoroacetylated lipopolyamine and dioleoyl phosphatidylethanolamine (Bio...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2009
ISSN: 0022-2275
DOI: 10.1194/jlr.r800064-jlr200